Structured Summary
Abstract
An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.
MeSH Record
Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
4 entry terms
- Procollagen N-Proteinase
- Procollagen Peptidase
- Procollagen N Endopeptidase
- Procollagen N Proteinase
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
97; was PROCOLLAGEN PEPTIDASE 1977-96 (see under ENDOPEPTIDASES 1977-90)
MeSH Record
Previous Indexing
- Collagen (1966-1976)
- Peptide Peptidohydrolases (1966-1976)
- Protein Precursors (1973-1976)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Procollagen N-Endopeptidase. Medical Subject Headings (MeSH). 2026. Unique ID D011348. http://id.nlm.nih.gov/mesh/2026/D011348
- Procollagen N-Endopeptidase. In: Wikipedia. https://en.wikipedia.org/wiki/Procollagen_peptidase
- Procollagen N-Endopeptidase. In: Wikidata. https://www.wikidata.org/wiki/Q7247456