Structured Summary
Abstract
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Chemical Identity
Chemical Information
- Molecular Formula
- C13H19NO4S
- Molecular Weight
- 285.36 g/mol
- CAS Registry No.
- 57-66-9
- IUPAC Name
- 4-(dipropylsulfamoyl)benzoic acid
- InChIKey
- DBABZHXKTCFAPX-UHFFFAOYSA-N
- SMILES
- CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
- MeSH Unique ID
- D011339
- Source
- PubChem CID 4911
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
6 entry terms
- Benecid
- Benemid
- Benuryl
- Pro-Cid
- Probecid
- Probenecid Weimer
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Probenecid. Medical Subject Headings (MeSH). 2026. Unique ID D011339. http://id.nlm.nih.gov/mesh/2026/D011339
- Probenecid. In: Wikipedia. https://en.wikipedia.org/wiki/Probenecid
- Probenecid. In: Wikidata. https://www.wikidata.org/wiki/Q900898
- Probenecid. In: PubChem Compound. CID 4911. https://pubchem.ncbi.nlm.nih.gov/compound/4911