Diseases

Primary Ovarian Insufficiency

Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.

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MeSH Record

Synonyms

20 entry terms
  • Ovarian Failure, Premature
  • Premature Ovarian Failure
  • Ovarian Insufficiency, Primary
  • FMR1-Related Primary Ovarian Insufficiency
  • Fragile X Premature Ovarian Failure
  • Fragile X-Associated Primary Ovarian Insufficiency
  • Gonadotropin-Resistant Ovary Syndrome
  • Hypergonadotropic Ovarian Failure, X-Linked
  • Premature Ovarian Failure 1
  • Premature Ovarian Failure, X-Linked
  • Primary Ovarian Insufficiency, Fragile X-Associated
  • Resistant Ovary Syndrome
  • X-Linked Hypergonadotropic Ovarian Failure
  • FMR1 Related Primary Ovarian Insufficiency
  • Fragile X Associated Primary Ovarian Insufficiency
  • Gonadotropin Resistant Ovary Syndrome
  • Hypergonadotropic Ovarian Failure, X Linked
  • Premature Ovarian Failure, X Linked
  • Primary Ovarian Insufficiency, Fragile X Associated
  • X Linked Hypergonadotropic Ovarian Failure

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2011(1992)

MeSH Record

Previous Indexing

  • Menopause, Premature (1975-1991)
  • Ovarian Diseases (1966-1991)

MeSH Hierarchy

Tree Numbers

  1. C12.050.351.500w.056.630w.750w
  2. C12.100w.250w.056.630w.750w
  3. C19w.391.630w.750w

AMA Style

References

  1. National Library of Medicine. Primary Ovarian Insufficiency. Medical Subject Headings (MeSH). 2026. Unique ID D016649. http://id.nlm.nih.gov/mesh/2026/D016649
  2. Primary Ovarian Insufficiency. In: Wikipedia. https://en.wikipedia.org/wiki/Primary_ovarian_insufficiency
  3. Primary Ovarian Insufficiency. In: Wikidata. https://www.wikidata.org/wiki/Q647630