Chemicals and Drugs

Presenilin-2

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

1 entry terms
  • Presenilin 2

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007

MeSH Record

Previous Indexing

  • Alzheimer Disease (1996-2006)
  • Membrane Proteins (1996-2006)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.696w.750

AMA Style

References

  1. National Library of Medicine. Presenilin-2. Medical Subject Headings (MeSH). 2026. Unique ID D053766. http://id.nlm.nih.gov/mesh/2026/D053766
  2. Presenilin-2. In: Wikidata. https://www.wikidata.org/wiki/Q21146236