Chemicals and Drugs

Presenilin-1

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

2 entry terms
  • Presenilin 1
  • S182 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007

MeSH Record

Previous Indexing

  • Alzheimer Disease (1995-2006)
  • Membrane Proteins (1995-2006)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.696w.500

AMA Style

References

  1. National Library of Medicine. Presenilin-1. Medical Subject Headings (MeSH). 2026. Unique ID D053764. http://id.nlm.nih.gov/mesh/2026/D053764
  2. Presenilin-1. In: Wikidata. https://www.wikidata.org/wiki/Q24727442