Chemicals and Drugs

Pregnenolone Carbonitrile

A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the potential for protective capability against acetaminophen-induced liver damage.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the potential for protective capability against acetaminophen-induced liver damage.

Chemical Identity

Chemical Information

Molecular Formula
C22H31NO2
Molecular Weight
341.5 g/mol
CAS Registry No.
1434-54-4
IUPAC Name
(3S,8S,9S,10R,13S,14S,16R,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile
InChIKey
VSBHRRMYCDQLJF-ZDNYCOCVSA-N
SMILES
CC(=O)[C@H]1[C@@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C#N
MeSH Unique ID
D011285
Source
PubChem CID 15032

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

7 entry terms
  • PCN
  • Pregnenolone 16 alpha-Carbonitrile
  • 16 alpha-Carbonitrile, Pregnenolone
  • Carbonitrile, Pregnenolone
  • Pregnenolone 16 alpha Carbonitrile
  • Pregnenolone Carbonitrile, (3 beta)-Isomer
  • Pregnenolone Carbonitrile, (3 beta,16 beta)-Isomer

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

74

MeSH Hierarchy

Tree Numbers

  1. D02w.626w.745w
  2. D04w.210.500w.745.745w.725w.703w

AMA Style

References

  1. National Library of Medicine. Pregnenolone Carbonitrile. Medical Subject Headings (MeSH). 2026. Unique ID D011285. http://id.nlm.nih.gov/mesh/2026/D011285
  2. Pregnenolone Carbonitrile. In: Wikipedia. https://en.wikipedia.org/wiki/Pregnenolone_16%CE%B1-carbonitrile
  3. Pregnenolone Carbonitrile. In: Wikidata. https://www.wikidata.org/wiki/Q7239909
  4. Pregnenolone Carbonitrile. In: PubChem Compound. CID 15032. https://pubchem.ncbi.nlm.nih.gov/compound/15032