Structured Summary
Abstract
A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
17 entry terms
- IGFBP-4 Metalloproteinase
- IGFBP-4 Protease
- IGFBP-4-Specific Proteinase
- Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease
- Insulin-Like-Growth Factor Binding Protein-4 Protease
- PAPP-A
- PAPP-alpha
- Pregnancy Associated alpha Plasma Protein
- Pregnancy-Associated alpha-Plasma Protein
- IGFBP 4 Metalloproteinase
- IGFBP 4 Protease
- Insulin Like Growth Factor Binding Protein 4 Protease
- Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease
- Metalloproteinase, IGFBP-4
- PAPP alpha
- Pregnancy Associated Plasma Protein A
- Protease, IGFBP-4
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2004 (1996)
MeSH Record
Previous Indexing
- Alpha Globulins (1966-1979)
- Alpha Macroglobulins (1976-1979)
- Blood Proteins (1966-1979)
- Glycoproteins (1966-1979)
- Pregnancy (1966-1979)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Pregnancy-Associated Plasma Protein-A. Medical Subject Headings (MeSH). 2026. Unique ID D011266. http://id.nlm.nih.gov/mesh/2026/D011266
- Pregnancy-Associated Plasma Protein-A. In: Wikipedia. https://en.wikipedia.org/wiki/Pappalysin-1
- Pregnancy-Associated Plasma Protein-A. In: Wikidata. https://www.wikidata.org/wiki/Q1476411