Structured Summary
Abstract
Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria, e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g., D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins and benanomicins have anti-HIV activities.
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Synonyms
13 entry terms
- Benanomicins and Pradimicins
- Pradimicin-Like Polyketides
- Pradimicin-Type Polyphenols
- Pradimicin Like Polyketides
- Pradimicin Type Polyphenols
- Benanomicin Antibiotics
- Benanomicin and Pradimicin Antibiotics
- Benanomicinones
- Benanomicins
- Pradimicin Antibiotics
- Pradimicin and Benanomicin Antibiotics
- Pradimicinones
- Pradimicins
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Aspects Covered
26 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2024
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AMA Style
References
- National Library of Medicine. Pradimicins and Benanomicins. Medical Subject Headings (MeSH). 2026. Unique ID D000095643. http://id.nlm.nih.gov/mesh/2026/D000095643
- Pradimicins and Benanomicins. In: Wikidata. https://www.wikidata.org/wiki/Q124242631