Structured Summary
Abstract
Normal cellular isoform of PRION PROTEINS encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.
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Classification
Broader headings
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MeSH Record
Synonyms
5 entry terms
- Cp 33-35
- Cp33-35, Scrapie
- PrP-sen
- Scrapie Amyloid Precursor Protein
- PrP sen
MeSH Record
Aspects Covered
31 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pathogenicity, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
PrPC stands for PRion Protein Cellular; do not confuse with PRPSC PROTEINS which are scrapie prion proteins
MeSH Record
History Note
95; SCRAPIE AMYLOID PRECURSOR PROTEIN was NM 1989-94
MeSH Record
Previous Indexing
- Prions (1992-1994)
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AMA Style
References
- National Library of Medicine. PrPC Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D018621. http://id.nlm.nih.gov/mesh/2026/D018621
- PrPC Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q76624839