Chemicals and Drugs

Polyomavirus Transforming Antigens

Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

21 entry terms
  • Antigens, Polyomavirus Transforming
  • Polyomavirus Tumor Antigens
  • Antigens, Polyomavirus Tumor
  • Transforming Antigens, Polyomavirus
  • Tumor Antigens, Polyomavirus
  • Polyomavirus Large T Antigens
  • Polyomavirus Middle T Antigens
  • Polyomavirus Small T Antigens
  • Polyomavirus T Proteins
  • Polyomaviruses Large T Proteins
  • Polyomaviruses Middle T Proteins
  • Polyomaviruses Small T Proteins
  • SV40 T Antigens
  • SV40 T Proteins
  • Simian Sarcoma Virus Proteins
  • Antigens, SV40 T
  • Proteins, Polyomavirus T
  • Proteins, SV40 T
  • T Antigens, SV40
  • T Proteins, Polyomavirus
  • T Proteins, SV40

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

coordinate with specific polyoma virus /immunol

MeSH Record

History Note

88

MeSH Record

Previous Indexing

  • Antigens, Viral (1973-1983)
  • Antigens, Viral, Tumor (1984-1987)
  • Oncogene Proteins, Viral (1986-1987)
  • Viral Proteins (1966-1985)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.624.664.520.090
  2. D12.776w.964w.350.062.090
  3. D12.776w.964w.700.090
  4. D23.050w.285.062.090
  5. D23.050w.327.062.090

AMA Style

References

  1. National Library of Medicine. Polyomavirus Transforming Antigens. Medical Subject Headings (MeSH). 2026. Unique ID D000952. http://id.nlm.nih.gov/mesh/2026/D000952
  2. Polyomavirus Transforming Antigens. In: Wikidata. https://www.wikidata.org/wiki/Q78143881