Chemicals and Drugs

Polymyxin B

A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.

Chemical Identity

Chemical Information

Molecular Formula
C56H98N16O13
Molecular Weight
1203.5 g/mol
IUPAC Name
N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide
InChIKey
WQVJHHACXVLGBL-UHFFFAOYSA-N
SMILES
CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O
MeSH Unique ID
D011112
Source
PubChem CID 4868

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • Aerosporin
  • Polymyxin B Sulfate

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1991(1978); was see under POLYMYXINS 1978-90; was AEROSPORIN see under POLYMYXIN 1971-77, see POLYMYXIN 1963-70; AEROSPORIN was see POLYMYXIN B 1978-93

MeSH Hierarchy

Tree Numbers

  1. D04w.345w.566w.780w.750w
  2. D10w.477w.750w.750w
  3. D12.644w.050.600w.750w
  4. D12.644w.066w.500.600w.750w
  5. D12.644w.641w.780w.750w
  6. D12.776w.543w.695w.054.600w.750w

AMA Style

References

  1. National Library of Medicine. Polymyxin B. Medical Subject Headings (MeSH). 2026. Unique ID D011112. http://id.nlm.nih.gov/mesh/2026/D011112
  2. Polymyxin B. In: Wikipedia. https://en.wikipedia.org/wiki/Polymyxin_B
  3. Polymyxin B. In: Wikidata. https://www.wikidata.org/wiki/Q1088175
  4. Polymyxin B. In: PubChem Compound. CID 4868. https://pubchem.ncbi.nlm.nih.gov/compound/4868