Structured Summary
Abstract
Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
13 entry terms
- Poly-Ig Receptor
- Polyimmunoglobulin Receptor
- Polymeric Ig Receptor
- Polymeric Immunoglobulin Receptor
- Receptor, Polyimmunoglobulin
- Receptor, Polymeric Ig
- Receptors, Polymeric Immunoglobulin
- Ig Receptor, Polymeric
- Immunoglobulin Receptor, Polymeric
- Immunoglobulin Receptors, Polymeric
- Poly Ig Receptor
- Receptor, Poly-Ig
- Receptor, Polymeric Immunoglobulin
MeSH Record
Aspects Covered
19 allowable subheadings
Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.
MeSH Record
History Note
96
MeSH Record
Previous Indexing
- Receptors, Immunologic (1989-1995)
- Secretory Component (1992-1995)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Polymeric Immunoglobulin Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D019056. http://id.nlm.nih.gov/mesh/2026/D019056
- Polymeric Immunoglobulin Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q7226563