Phenomena and Processes

Polyadenylation

The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.

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Broader headings

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MeSH Record

Synonyms

1 entry terms
  • Polyadenylations

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2002

MeSH Record

Previous Indexing

  • Poly A/metabolism (1975-2001)
  • RNA, Messenger/metabolism (1974-2001)

MeSH Hierarchy

Tree Numbers

  1. G02.111.760w.225.710w
  2. G03w.839w.225.710w
  3. G05.308w.700w.225.710w

AMA Style

References

  1. National Library of Medicine. Polyadenylation. Medical Subject Headings (MeSH). 2026. Unique ID D026723. http://id.nlm.nih.gov/mesh/2026/D026723
  2. Polyadenylation. In: Wikipedia. https://en.wikipedia.org/wiki/Polyadenylation
  3. Polyadenylation. In: Wikidata. https://www.wikidata.org/wiki/Q412148