Chemicals and Drugs

Poly (ADP-Ribose) Polymerase-1

A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin architecture and BASE EXCISION REPAIR with POLY ADENOSINE DIPHOSPHATE RIBOSE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin architecture and BASE EXCISION REPAIR with POLY ADENOSINE DIPHOSPHATE RIBOSE.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

6 entry terms
  • NAD+ ADP-ribosyltransferase-1
  • PARP-1 Protein
  • PARP1 Protein
  • Poly (ADP-Ribose) Synthase-1
  • NAD+ ADP ribosyltransferase 1
  • PARP 1 Protein

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • ADP Ribose Transferases (2006-2016)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.400w.725w.115.690w.420

AMA Style

References

  1. National Library of Medicine. Poly (ADP-Ribose) Polymerase-1. Medical Subject Headings (MeSH). 2026. Unique ID D000071137. http://id.nlm.nih.gov/mesh/2026/D000071137
  2. Poly (ADP-Ribose) Polymerase-1. In: Wikidata. https://www.wikidata.org/wiki/Q75077515