Chemicals and Drugs

Podophyllin

Caustic extract from the roots of Podophyllum peltatum and P. emodi. It contains PODOPHYLLOTOXIN and its congeners and is very irritating to mucous membranes and skin. Podophyllin is a violent purgative that may cause CNS damage and teratogenesis. It is used as a paint for warts, skin neoplasms, and senile keratoses.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Caustic extract from the roots of Podophyllum peltatum and P. emodi. It contains PODOPHYLLOTOXIN and its congeners and is very irritating to mucous membranes and skin. Podophyllin is a violent purgative that may cause CNS damage and teratogenesis. It is used as a paint for warts, skin neoplasms, and senile keratoses.

Chemical Identity

Chemical Information

Molecular Formula
C88H92O34
Molecular Weight
1693.6 g/mol
CAS Registry No.
9000-55-9
IUPAC Name
bis(8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxole-6-carboxylic acid);bis(5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one)
InChIKey
KOUZYZCESNTXJO-UHFFFAOYSA-N
SMILES
COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O.COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O.COC1=CC(=CC(=C1OC)OC)C2C(C(C(C3=CC4=C(C=C23)OCO4)O)CO)C(=O)O.COC1=CC(=CC(=C1OC)OC)C2C(C(C(C3=CC4=C(C=C23)OCO4)O)CO)C(=O)O
MeSH Unique ID
D011033
Source
PubChem CID 11979494

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • Podophyllum Resin
  • Resin, Podophyllum

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

72(64); was see under PODOPHYLLUM 1963-71

MeSH Hierarchy

Tree Number

  1. D20.215.784.500.675w

AMA Style

References

  1. National Library of Medicine. Podophyllin. Medical Subject Headings (MeSH). 2026. Unique ID D011033. http://id.nlm.nih.gov/mesh/2026/D011033
  2. Podophyllin. In: Wikipedia. https://en.wikipedia.org/wiki/Podophyllum_resin
  3. Podophyllin. In: Wikidata. https://www.wikidata.org/wiki/Q22075831
  4. Podophyllin. In: PubChem Compound. CID 11979494. https://pubchem.ncbi.nlm.nih.gov/compound/11979494