Chemicals and Drugs

Pirenzepine

An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

Chemical Identity

Chemical Information

Molecular Formula
C19H21N5O2
Molecular Weight
351.4 g/mol
CAS Registry No.
28797-61-7
IUPAC Name
11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one
InChIKey
RMHMFHUVIITRHF-UHFFFAOYSA-N
SMILES
CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
MeSH Unique ID
D010890
Source
PubChem CID 4848

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

18 entry terms
  • Pirenzepin
  • Pyrenzepine
  • Gastrotsepin
  • Gastrozepin
  • L-S 519
  • LS-519
  • Piren-Basan
  • Pirenzepin Von Ct
  • Pirenzepin-Ratiopharm
  • Pirenzepine Dihydrochloride
  • Ulcoprotect
  • Ulgescum
  • Dihydrochloride, Pirenzepine
  • LS 519
  • LS519
  • Piren Basan
  • Pirenzepin Ratiopharm
  • Von Ct, Pirenzepin

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

87

MeSH Record

Previous Indexing

  • Azepines (1966-1973)
  • Benzodiazepinones (1974-1986)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.079.080w.070.750w

AMA Style

References

  1. National Library of Medicine. Pirenzepine. Medical Subject Headings (MeSH). 2026. Unique ID D010890. http://id.nlm.nih.gov/mesh/2026/D010890
  2. Pirenzepine. In: Wikipedia. https://en.wikipedia.org/wiki/Pirenzepine
  3. Pirenzepine. In: Wikidata. https://www.wikidata.org/wiki/Q419550
  4. Pirenzepine. In: PubChem Compound. CID 4848. https://pubchem.ncbi.nlm.nih.gov/compound/4848