Chemicals and Drugs

Physalaemin

An oligopeptide isolated from the skin of Physalaemus fuscumaculatus, a South American frog. It is a typical kinin, resembling SUBSTANCE P in structure and action and has been proposed as a sialagogue, antihypertensive, and vasodilator.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An oligopeptide isolated from the skin of Physalaemus fuscumaculatus, a South American frog. It is a typical kinin, resembling SUBSTANCE P in structure and action and has been proposed as a sialagogue, antihypertensive, and vasodilator.

Chemical Identity

Chemical Information

Molecular Formula
C58H84N14O16S
Molecular Weight
1265.4 g/mol
CAS Registry No.
2507-24-6
IUPAC Name
(3S)-4-[(2S)-2-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxo-3-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]butanoic acid
InChIKey
SHSUJLMLURFKID-YFUSJSQUSA-N
SMILES
C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@@H]4CCC(=O)N4
MeSH Unique ID
D010803
Source
PubChem CID 14717795

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

1 entry terms
  • Physalemin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(77); was see under TACHYKININS 1989-90; was see under KININS 1977-88

MeSH Record

Previous Indexing

  • Peptides (1969-1976)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.812w.900w.800w
  2. D12.644w.400w.800w.625w
  3. D12.644w.456w.800w.745w
  4. D12.776w.467.812w.900w.800w
  5. D12.776w.631w.650w.800w.625w
  6. D20.888w.033.728w
  7. D23.469.050w.375w.850w.780w
  8. D23.529.812w.900w.800w
  9. D23.946w.833w.033.728w

AMA Style

References

  1. National Library of Medicine. Physalaemin. Medical Subject Headings (MeSH). 2026. Unique ID D010803. http://id.nlm.nih.gov/mesh/2026/D010803
  2. Physalaemin. In: Wikipedia. https://en.wikipedia.org/wiki/Physalaemin
  3. Physalaemin. In: Wikidata. https://www.wikidata.org/wiki/Q113510406
  4. Physalaemin. In: PubChem Compound. CID 14717795. https://pubchem.ncbi.nlm.nih.gov/compound/14717795