Chemicals and Drugs

Phosphofructokinase-2

An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

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See Also

MeSH Record

Synonyms

17 entry terms
  • 6-Phosphofructo-2-kinase
  • 6PF2K
  • ATP-D-Fructose-6-phosphate 2-phosphotransferase
  • Fru-6-P,2-kinase
  • Fructose-6-P,2-kinase
  • Fructose-6-phosphate,2-kinase
  • Phosphofructokinase 2
  • 6-PF-2-K-Fru-2,6-P(2)ase
  • 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase
  • 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase
  • F Kinase-F-bisphosphatase
  • Fru-kinase-Fru-bisphosphatase
  • Fructose 2,6-bisphosphatase
  • Fructose-2,6-bisphosphatase
  • Fructose-2,6-bisphosphate 2-phosphatase
  • Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase
  • fructose-2,6-diphosphatase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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History Note

2002; for 6-PHOSPHOFRUCTO-2-KINASE use PHOSPHOTRANSFERASES (NM) 1993-2001, use PHOSPHOTRANSFERASES, ATP (NM) 1981-1993; for FRUCTOSE-2,6-BISPHOSPATASE use PHOSPHORIC MONOESTER HYDROLASES (NM) 1983-2001; for 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE use FRUCTOSE-BISPHOSPHATASE (NM) 1990-2001, use MULTIENZYME COMPLEXES (NM) 1990-2001, use PHOSPHOFRUCTOKINASE-1 (NM) 1990-2001

MeSH Record

Previous Indexing

  • Phosphofructokinase-1 (1981-2001)
  • Phosphoric Monoester Hydrolases (1983-2001)
  • Phosphotransferases (1981-2001)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.650w.622w
  2. D08.811w.641.843w
  3. D08.811w.913w.696w.620.225w.850w.750w

AMA Style

References

  1. National Library of Medicine. Phosphofructokinase-2. Medical Subject Headings (MeSH). 2026. Unique ID D025481. http://id.nlm.nih.gov/mesh/2026/D025481
  2. Phosphofructokinase-2. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphofructokinase_2
  3. Phosphofructokinase-2. In: Wikidata. https://www.wikidata.org/wiki/Q420663