Structured Summary
Abstract
A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.
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Classification
Broader headings
Related Concepts
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Synonyms
13 entry terms
- 5'-Exonuclease
- 5'-Nucleotidephosphodiesterase
- Alkaline Phosphodiesterase
- Alkaline Phosphodiesterase I
- Oligonucleate 5'-Nucleotidohydrolase
- Orthophosphoric Diester Phosphohydrolase
- 5' Exonuclease
- 5' Nucleotidephosphodiesterase
- Diester Phosphohydrolase, Orthophosphoric
- Oligonucleate 5' Nucleotidohydrolase
- Phosphodiesterase I, Alkaline
- Phosphodiesterase, Alkaline
- Phosphohydrolase, Orthophosphoric Diester
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2004; use PHOSPHODIESTERASE I (NM) 1980-2003
MeSH Record
Previous Indexing
- Phosphoric Diester Hydrolases (1978-2003)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Phosphodiesterase I. Medical Subject Headings (MeSH). 2026. Unique ID D043264. http://id.nlm.nih.gov/mesh/2026/D043264
- Phosphodiesterase I. In: Wikipedia. https://en.wikipedia.org/wiki/PDE1
- Phosphodiesterase I. In: Wikidata. https://www.wikidata.org/wiki/Q5864323