Chemicals and Drugs

Phosphatidylinositol Diacylglycerol-Lyase

A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a TYPE C PHOSPHOLIPASES. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a TYPE C PHOSPHOLIPASES. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • 1-Phosphatidylinositol Phosphodiesterase
  • Monophosphatidylinositol Phosphodiesterase
  • 1 Phosphatidylinositol Phosphodiesterase
  • Diacylglycerol-Lyase, Phosphatidylinositol
  • Phosphatidylinositol Diacylglycerol Lyase
  • Phosphodiesterase, 1-Phosphatidylinositol
  • Phosphodiesterase, Monophosphatidylinositol

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

note X refs: TYPE C PHOSPHOLIPASES is also available

MeSH Record

History Note

2004; use PHOSPHOTIDYLINOSITOL DIACYLGLYCEROL-LYASE (NM) 1980-2003

MeSH Record

Previous Indexing

  • Phosphatidylinositols (1977-1982)
  • Phospholipase C (1998-2003)
  • Phosphoric Diester Hydrolases (1976-1997)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.640.700w.700w.500w
  2. D08.811w.520w.650.800w

AMA Style

References

  1. National Library of Medicine. Phosphatidylinositol Diacylglycerol-Lyase. Medical Subject Headings (MeSH). 2026. Unique ID D043265. http://id.nlm.nih.gov/mesh/2026/D043265
  2. Phosphatidylinositol Diacylglycerol-Lyase. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase
  3. Phosphatidylinositol Diacylglycerol-Lyase. In: Wikidata. https://www.wikidata.org/wiki/Q7187463