Chemicals and Drugs

Phosphatidylcholine-Sterol O-Acyltransferase

An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

11 entry terms
  • Cholesterol Ester Lysolecithin Acyltransferase
  • Lecithin Acyltransferase
  • Lecithin Cholesterol Acyltransferase
  • Phosophatidylcholine-Sterol Acyltransferase
  • Acyltransferase, Lecithin
  • Acyltransferase, Lecithin Cholesterol
  • Acyltransferase, Phosophatidylcholine-Sterol
  • Cholesterol Acyltransferase, Lecithin
  • O-Acyltransferase, Phosphatidylcholine-Sterol
  • Phosophatidylcholine Sterol Acyltransferase
  • Phosphatidylcholine Sterol O Acyltransferase

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

98(75)

MeSH Record

Previous Indexing

  • Acyltransferases (1966-1974)
  • Cholesterol (1966-1974)
  • Phosphatidylcholines (1966-1974)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.050w.625w

MeSH Record

NLM Classification

QU 141

AMA Style

References

  1. National Library of Medicine. Phosphatidylcholine-Sterol O-Acyltransferase. Medical Subject Headings (MeSH). 2026. Unique ID D007862. http://id.nlm.nih.gov/mesh/2026/D007862
  2. Phosphatidylcholine-Sterol O-Acyltransferase. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphatidylcholine%E2%80%94sterol_O-acyltransferase
  3. Phosphatidylcholine-Sterol O-Acyltransferase. In: Wikidata. https://www.wikidata.org/wiki/Q17130623