Phenomena and Processes

Phase I Metabolic Detoxication

Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

11 entry terms
  • Metabolic Detoxication, Oxidative
  • Metabolic Detoxication, Phase I
  • Metabolic Detoxification, Phase I
  • Phase I Detoxification
  • Detoxication, Oxidative Metabolic
  • Detoxications, Oxidative Metabolic
  • Detoxification, Phase I
  • Detoxifications, Phase I
  • Metabolic Detoxications, Oxidative
  • Oxidative Metabolic Detoxication
  • Oxidative Metabolic Detoxications

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings ethnology, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2006

MeSH Hierarchy

Tree Numbers

  1. G03w.171w.450.500
  2. G03w.787w.225w.450.500
  3. G07.690.725w.225w.450.500

AMA Style

References

  1. National Library of Medicine. Phase I Metabolic Detoxication. Medical Subject Headings (MeSH). 2026. Unique ID D050216. http://id.nlm.nih.gov/mesh/2026/D050216
  2. Phase I Metabolic Detoxication. In: Wikidata. https://www.wikidata.org/wiki/Q71159692