Structured Summary
Abstract
Naturally occurring genetic variations associated with drug response (e.g., dosage, extent and rate of metabolic processes). While these variants are not markers for GENETIC PREDISPOSITION TO DISEASE they influence PHARMACOKINETICS and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., ANGIOTENSIN CONVERTING ENZYME; CYTOCHROME P-450 CYP2D6).
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Synonyms
11 entry terms
- Pharmacogenetic Variants
- Pharmacokinetic Genetic Variants
- Genetic Variant, Pharmacokinetic
- Genetic Variants, Pharmacokinetic
- Pharmacogenetic Variant
- Pharmacogenomic Variant
- Pharmacokinetic Genetic Variant
- Variant, Pharmacogenetic
- Variant, Pharmacogenomic
- Variants, Pharmacogenetic
- Variants, Pharmacogenomic
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Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
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History Note
2017
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Previous Indexing
- Genetic Variation (1968-2016)
- Pharmacogenetics (1968-2016)
- Polymorphism, Genetic (1980-2016)
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References
- National Library of Medicine. Pharmacogenomic Variants. Medical Subject Headings (MeSH). 2026. Unique ID D000071184. http://id.nlm.nih.gov/mesh/2026/D000071184
- Pharmacogenomic Variants. In: Wikidata. https://www.wikidata.org/wiki/Q71227267