Diseases

Persistent Fetal Circulation Syndrome

A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).

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Classification

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See Also

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Synonyms

13 entry terms
  • ACD-MPV
  • ACDMPV
  • Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
  • Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins And Other Congenital Anomalies
  • Circulation, Persistent Fetal
  • Familial Persistent Pulmonary Hypertension of the Newborn
  • Fetal Circulation, Persistent
  • Hypertension, Pulmonary, of Newborn, Persistent
  • Misalignment of the Pulmonary Vessels
  • Persistent Fetal Circulation
  • Persistent Pulmonary Hypertension of Newborn
  • Pulmonary Hypertension, Familial Persistent, of the Newborn
  • ACD MPV

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

also known as PPHN check the tags HUMANS & INFANT, NEWBORN

MeSH Record

History Note

1980

MeSH Record

Previous Indexing

  • Ductus Arteriosus, Patent (1966-1979)
  • Hypertension, Pulmonary (1966-1979)
  • Pulmonary Circulation (1966-1979)

MeSH Hierarchy

Tree Numbers

  1. C08w.381.423w.694w
  2. C16w.614.694w

AMA Style

References

  1. National Library of Medicine. Persistent Fetal Circulation Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D010547. http://id.nlm.nih.gov/mesh/2026/D010547
  2. Persistent Fetal Circulation Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Persistent_fetal_circulation
  3. Persistent Fetal Circulation Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q7170410