Structured Summary
Abstract
A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.
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Synonyms
9 entry terms
- PAT Proteins
- PLIN Proteins
- Perilipin Proteins
- Perilipin-Adipophilin-TIP47 Proteins
- Perilipin Adipophilin TIP47 Proteins
- Proteins, PAT
- Proteins, PLIN
- Proteins, Perilipin
- Proteins, Perilipin-Adipophilin-TIP47
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Carrier Proteins (1991-2016)
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AMA Style
References
- National Library of Medicine. Perilipins. Medical Subject Headings (MeSH). 2026. Unique ID D000070137. http://id.nlm.nih.gov/mesh/2026/D000070137
- Perilipins. In: Wikidata. https://www.wikidata.org/wiki/Q24768264