Structured Summary
Abstract
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
MeSH Record
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Broader headings
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
5 entry terms
- Cytolysin
- Lymphocyte Pore-Forming Protein
- Perforin 1
- Lymphocyte Pore Forming Protein
- Pore-Forming Protein, Lymphocyte
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2008
MeSH Record
Previous Indexing
- Membrane Glycoproteins (1985-2007)
- Pore Forming Cytotoxic Proteins (1985-2007)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Perforin. Medical Subject Headings (MeSH). 2026. Unique ID D054353. http://id.nlm.nih.gov/mesh/2026/D054353
- Perforin. In: Wikipedia. https://en.wikipedia.org/wiki/Perforin-1
- Perforin. In: Wikidata. https://www.wikidata.org/wiki/Q21103279