Chemicals and Drugs

Peptidyl-Dipeptidase A

A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide--Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide--Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020).

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

17 entry terms
  • ACE1 Angiotensin-Converting Enzyme 1
  • ACE1 Protein
  • Angiotensin Converting Enzyme
  • Angiotensin Converting Enzyme 1
  • Angiotensin I-Converting Enzyme
  • Antigens, CD143
  • CD143 Antigens
  • Carboxycathepsin
  • Dipeptidyl Carboxypeptidase I
  • Dipeptidyl Peptidase A
  • Kininase A
  • Kininase II
  • Peptidase P
  • ACE1 Angiotensin Converting Enzyme 1
  • Angiotensin I Converting Enzyme
  • Carboxypeptidase I, Dipeptidyl
  • Peptidyl Dipeptidase A

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1994; for TONIN use KININASE II 1984-93

MeSH Record

Previous Indexing

  • Peptide Peptidohydrolases (1966-1972)

MeSH Hierarchy

Tree Number

  1. D08.811w.277w.656w.350w.350.687w

AMA Style

References

  1. National Library of Medicine. Peptidyl-Dipeptidase A. Medical Subject Headings (MeSH). 2026. Unique ID D007703. http://id.nlm.nih.gov/mesh/2026/D007703
  2. Peptidyl-Dipeptidase A. In: Wikipedia. https://en.wikipedia.org/wiki/Angiotensin-converting_enzyme
  3. Peptidyl-Dipeptidase A. In: Wikidata. https://www.wikidata.org/wiki/Q128861