Chemicals and Drugs

Peptide T

N-(N-(N(2)-(N-(N-(N-(N-D-Alanyl L-seryl)-L-threonyl)-L-threonyl) L-threonyl)-L-asparaginyl)-L-tyrosyl) L-threonine. Octapeptide sharing sequence homology with HIV envelope protein gp120. It is potentially useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

N-(N-(N(2)-(N-(N-(N-(N-D-Alanyl L-seryl)-L-threonyl)-L-threonyl) L-threonyl)-L-asparaginyl)-L-tyrosyl) L-threonine. Octapeptide sharing sequence homology with HIV envelope protein gp120. It is potentially useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor.

Chemical Identity

Chemical Information

Molecular Formula
C35H55N9O16
Molecular Weight
857.9 g/mol
CAS Registry No.
106362-32-7
IUPAC Name
(2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoic acid
InChIKey
IWHCAJPPWOMXNW-LYKMMFCUSA-N
SMILES
C[C@H]([C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C)N)O
MeSH Unique ID
D015717
Source
PubChem CID 73352

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

2 entry terms
  • HIV Peptide T
  • Peptide T, HIV

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

/biosyn /drug eff /physiol permitted

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Oligopeptides (1987-1989)
  • Peptide Fragments (1987-1989)

MeSH Hierarchy

Tree Number

  1. D12.644w.456w.729w

AMA Style

References

  1. National Library of Medicine. Peptide T. Medical Subject Headings (MeSH). 2026. Unique ID D015717. http://id.nlm.nih.gov/mesh/2026/D015717
  2. Peptide T. In: Wikipedia. https://en.wikipedia.org/wiki/Peptide_T
  3. Peptide T. In: Wikidata. https://www.wikidata.org/wiki/Q7166522
  4. Peptide T. In: PubChem Compound. CID 73352. https://pubchem.ncbi.nlm.nih.gov/compound/73352