Chemicals and Drugs

Peptide PHI

A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

28 entry terms
  • Neuropeptide PHI 27
  • PHI Peptide
  • PHM Neuropeptide
  • PHM-27
  • Peptide HI
  • Peptide Histidine Methionine
  • Peptide Histidine-Isoleucine
  • Peptide PHI-27
  • Peptide PHM
  • Peptide-Histidine-Isoleucinamide
  • Pro-Vasoactive Intestinal Peptide
  • Histidine Methionine, Peptide
  • Histidine-Isoleucine, Peptide
  • Intestinal Peptide, Pro-Vasoactive
  • Methionine, Peptide Histidine
  • Neuropeptide, PHM
  • PHM, Peptide
  • Peptide Histidine Isoleucinamide
  • Peptide Histidine Isoleucine
  • Peptide PHI 27
  • Peptide, PHI
  • Peptide, Pro-Vasoactive Intestinal
  • Pro Vasoactive Intestinal Peptide
  • Human PHI
  • Porcine Intestinal Heptacosapeptide
  • Heptacosapeptide, Porcine Intestinal
  • Intestinal Heptacosapeptide, Porcine
  • PHI, Human

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

a neurotransmitter; entry term explains PHI

MeSH Record

History Note

87

MeSH Record

Previous Indexing

  • Gastrointestinal Hormones (1966-1986)
  • Peptides (1966-1986)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.592w
  2. D12.644w.400w.610w
  3. D12.644w.548w.592w
  4. D12.776w.631w.650w.610w

AMA Style

References

  1. National Library of Medicine. Peptide PHI. Medical Subject Headings (MeSH). 2026. Unique ID D010451. http://id.nlm.nih.gov/mesh/2026/D010451
  2. Peptide PHI. In: Wikipedia. https://en.wikipedia.org/wiki/Peptide_PHI
  3. Peptide PHI. In: Wikidata. https://www.wikidata.org/wiki/Q7166520