Chemicals and Drugs

Pentylenetetrazole

A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.

Chemical Identity

Chemical Information

Molecular Formula
C6H10N4
Molecular Weight
138.17 g/mol
CAS Registry No.
54-95-5
IUPAC Name
6,7,8,9-tetrahydro-5H-tetrazolo[1,5-a]azepine
InChIKey
CWRVKFFCRWGWCS-UHFFFAOYSA-N
SMILES
C1CCC2=NN=NN2CC1
MeSH Unique ID
D010433
Source
PubChem CID 5917

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

13 entry terms
  • Leptazole
  • Pentamethylenetetrazole
  • Pentetrazole
  • Pentylenetetrazol
  • Cardiazol
  • Corasol
  • Corazol
  • Corazole
  • Korazol
  • Korazole
  • Metrazol
  • Metrazole
  • Pentazol

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. Pentylenetetrazole. Medical Subject Headings (MeSH). 2026. Unique ID D010433. http://id.nlm.nih.gov/mesh/2026/D010433
  2. Pentylenetetrazole. In: Wikipedia. https://en.wikipedia.org/wiki/Pentylenetetrazol
  3. Pentylenetetrazole. In: Wikidata. https://www.wikidata.org/wiki/Q412391
  4. Pentylenetetrazole. In: PubChem Compound. CID 5917. https://pubchem.ncbi.nlm.nih.gov/compound/5917