Structured Summary
Abstract
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
Chemical Identity
Chemical Information
- Molecular Formula
- C13H18N4O3
- Molecular Weight
- 278.31 g/mol
- CAS Registry No.
- 6493-05-6
- IUPAC Name
- 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
- InChIKey
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N
- SMILES
- CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C
- MeSH Unique ID
- D010431
- Source
- PubChem CID 4740
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- Oxpentifylline
- Agapurin
- BL-191
- Pentoxil
- Torental
- Trental
- BL 191
- BL191
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
91(77)
MeSH Record
Previous Indexing
- Xanthines (1972-1976)
MeSH Hierarchy
Tree Number
MeSH Record
NLM Classification
QV 107
AMA Style
References
- National Library of Medicine. Pentoxifylline. Medical Subject Headings (MeSH). 2026. Unique ID D010431. http://id.nlm.nih.gov/mesh/2026/D010431
- Pentoxifylline. In: Wikipedia. https://en.wikipedia.org/wiki/Pentoxifylline
- Pentoxifylline. In: Wikidata. https://www.wikidata.org/wiki/Q416331
- Pentoxifylline. In: PubChem Compound. CID 4740. https://pubchem.ncbi.nlm.nih.gov/compound/4740