Diseases

Pentalogy of Cantrell

Rare congenital deformity syndrome characterized by a combination of five anomalies as a result of neural tube defect. The five anomalies are a midline supraumbilical abdominal wall defect (e.g., OMPHALOCELE), a lower STERNUM defect, a congenital intracardiac defect, an anterior DIAPHRAGM defect, and a diaphragmatic PERICARDIUM defect (e.g., PERICARDIAL EFFUSION). Variants with incomplete and variable combinations of the defects are known. ECTOPIA CORDIS; CLEFT LIP; and CLEFT PALATE are often associated with the syndrome.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Rare congenital deformity syndrome characterized by a combination of five anomalies as a result of neural tube defect. The five anomalies are a midline supraumbilical abdominal wall defect (e.g., OMPHALOCELE), a lower STERNUM defect, a congenital intracardiac defect, an anterior DIAPHRAGM defect, and a diaphragmatic PERICARDIUM defect (e.g., PERICARDIAL EFFUSION). Variants with incomplete and variable combinations of the defects are known. ECTOPIA CORDIS; CLEFT LIP; and CLEFT PALATE are often associated with the syndrome.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

8 entry terms
  • Cantrell Haller Ravitch syndrome
  • Cantrell Pentalogy
  • Cantrell's Pentalogy
  • Thoracoabdominal Syndrome
  • Cantrells Pentalogy
  • Pentalogy, Cantrell
  • Pentalogy, Cantrell's
  • Thoracoabdominal Syndromes

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2011

MeSH Record

Previous Indexing

  • Abnormalities, Multiple (1984-2010)

MeSH Hierarchy

Tree Numbers

  1. C10w.500w.680w.705w
  2. C16w.131w.077w.696w
  3. C16w.131w.666w.680w.705w

AMA Style

References

  1. National Library of Medicine. Pentalogy of Cantrell. Medical Subject Headings (MeSH). 2026. Unique ID D058502. http://id.nlm.nih.gov/mesh/2026/D058502
  2. Pentalogy of Cantrell. In: Wikipedia. https://en.wikipedia.org/wiki/Pentalogy_of_Cantrell
  3. Pentalogy of Cantrell. In: Wikidata. https://www.wikidata.org/wiki/Q7165022