Diseases

Paroxysmal Hemoglobinuria

A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

14 entry terms
  • Hemoglobinuria, Paroxysmal
  • Marchiafava-Micheli Syndrome
  • Paroxysmal Cold Hemoglobinuria
  • Paroxysmal Hemoglobinuria, Cold
  • Paroxysmal Hemoglobinuria, Nocturnal
  • Paroxysmal Nocturnal Hemoglobinuria
  • Cold Paroxysmal Hemoglobinuria
  • Hemoglobinuria, Cold Paroxysmal
  • Hemoglobinuria, Nocturnal Paroxysmal
  • Hemoglobinuria, Paroxysmal Cold
  • Hemoglobinuria, Paroxysmal Nocturnal
  • Marchiafava Micheli Syndrome
  • Nocturnal Paroxysmal Hemoglobinuria
  • Syndrome, Marchiafava-Micheli

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

78; was MARCHIAFAVA-MICHELI SYNDROME 1963-77

MeSH Hierarchy

Tree Numbers

  1. C15.378w.050w.141w.560w
  2. C15.378w.190.625w.460w

MeSH Record

NLM Classification

WH 385

AMA Style

References

  1. National Library of Medicine. Paroxysmal Hemoglobinuria. Medical Subject Headings (MeSH). 2026. Unique ID D006457. http://id.nlm.nih.gov/mesh/2026/D006457
  2. Paroxysmal Hemoglobinuria. In: Wikipedia. https://en.wikipedia.org/wiki/Paroxysmal_nocturnal_hemoglobinuria
  3. Paroxysmal Hemoglobinuria. In: Wikidata. https://www.wikidata.org/wiki/Q1479494