Chemicals and Drugs

Paramethasone

A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than HYDROCORTISONE with supplementary FLUDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than HYDROCORTISONE with supplementary FLUDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737)

Chemical Identity

Chemical Information

Molecular Formula
C22H29FO5
Molecular Weight
392.5 g/mol
CAS Registry No.
53-33-8
IUPAC Name
(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
InChIKey
MKPDWECBUAZOHP-AFYJWTTESA-N
SMILES
C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)F
MeSH Unique ID
D010248
Source
PubChem CID 5875

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

65(63)

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.745.432w.769.692w
  2. D04w.210.500w.908.727w

AMA Style

References

  1. National Library of Medicine. Paramethasone. Medical Subject Headings (MeSH). 2026. Unique ID D010248. http://id.nlm.nih.gov/mesh/2026/D010248
  2. Paramethasone. In: Wikipedia. https://en.wikipedia.org/wiki/Paramethasone
  3. Paramethasone. In: Wikidata. https://www.wikidata.org/wiki/Q7135218
  4. Paramethasone. In: PubChem Compound. CID 5875. https://pubchem.ncbi.nlm.nih.gov/compound/5875