Chemicals and Drugs

Pancreatitis-Associated Proteins

C-type lectins that restrict growth of bacteria in the intestinal epithelia and have bactericidal activity against gram-positive and gram-negative bacteria. They also regulate proliferation and differentiation of KERATINOCYTES following injury. Human pancreatitis-associated protein-1 (Reg3a) is overexpressed by pancreatic ACINAR CELLS in patients with CHRONIC PANCREATITIS. It is also highly expressed by pancreatic, bladder, and gastrointestinal cancer cells and may serve as a diagnostic biomarker.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

C-type lectins that restrict growth of bacteria in the intestinal epithelia and have bactericidal activity against gram-positive and gram-negative bacteria. They also regulate proliferation and differentiation of KERATINOCYTES following injury. Human pancreatitis-associated protein-1 (Reg3a) is overexpressed by pancreatic ACINAR CELLS in patients with CHRONIC PANCREATITIS. It is also highly expressed by pancreatic, bladder, and gastrointestinal cancer cells and may serve as a diagnostic biomarker.

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MeSH Record

Synonyms

14 entry terms
  • Regenerating Islet-Derived Protein
  • Regenerating Islet-Derived Proteins
  • Islet-Derived Protein, Regenerating
  • Pancreatitis Associated Proteins
  • Protein, Regenerating Islet-Derived
  • Regenerating Islet Derived Protein
  • Regenerating Islet Derived Proteins
  • Pancreatitis-Associated Protein
  • Pancreatitis-Associated Protein-1
  • Regenerating Islet-Derived Protein 3
  • Pancreatitis Associated Protein
  • Pancreatitis Associated Protein 1
  • Protein, Pancreatitis-Associated
  • Regenerating Islet Derived Protein 3

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1992)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.503w.280.578
  2. D23.050w.285.733
  3. D23.101w.140.780

AMA Style

References

  1. National Library of Medicine. Pancreatitis-Associated Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D000073718. http://id.nlm.nih.gov/mesh/2026/D000073718
  2. Pancreatitis-Associated Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q110397265