Chemicals and Drugs

Pancreatic Polypeptide

A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • Pancreatic Polypeptide (PP)
  • Pancreatic Polypeptide Hormone
  • Pancreatic Prohormone

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

79

MeSH Record

Previous Indexing

  • Hormones (1966-1973)
  • Pancreatic Hormones (1974-1978)
  • Peptides (1966-1978)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.587.700w
  2. D12.644w.400w.600w
  3. D12.644w.548w.586.700w
  4. D12.776w.631w.650w.600w

AMA Style

References

  1. National Library of Medicine. Pancreatic Polypeptide. Medical Subject Headings (MeSH). 2026. Unique ID D010191. http://id.nlm.nih.gov/mesh/2026/D010191
  2. Pancreatic Polypeptide. In: Wikipedia. https://en.wikipedia.org/wiki/Pancreatic_polypeptide
  3. Pancreatic Polypeptide. In: Wikidata. https://www.wikidata.org/wiki/Q246978