Chemicals and Drugs

Paliperidone Palmitate

A benzisoxazole derivative and active metabolite of RISPERIDONE that functions as a DOPAMINE D2 RECEPTOR ANTAGONIST and SEROTONIN 5-HT2 RECEPTOR ANTAGONIST. It is an ANTIPSYCHOTIC AGENT used in the treatment of SCHIZOPHRENIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A benzisoxazole derivative and active metabolite of RISPERIDONE that functions as a DOPAMINE D2 RECEPTOR ANTAGONIST and SEROTONIN 5-HT2 RECEPTOR ANTAGONIST. It is an ANTIPSYCHOTIC AGENT used in the treatment of SCHIZOPHRENIA.

Chemical Identity

Chemical Information

Molecular Formula
C39H57FN4O4
Molecular Weight
664.9 g/mol
CAS Registry No.
199739-10-1
IUPAC Name
[3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl] hexadecanoate
InChIKey
VOMKSBFLAZZBOW-UHFFFAOYSA-N
SMILES
CCCCCCCCCCCCCCCC(=O)OC1CCCN2C1=NC(=C(C2=O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F)C
MeSH Unique ID
D000068882
Source
PubChem CID 9852746

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • Palmitate, Paliperidone
  • 3-(2-(4-(6-fluoro-3-(1,2-benzisoxazolyl))-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one
  • 9-Hydroxy-risperidone
  • 9-Hydroxyrisperidone
  • 9-OH-risperidone
  • Invega
  • Invega Sustenna
  • Paliperidone
  • R 76477
  • R-76477
  • 9 Hydroxy risperidone
  • 9 Hydroxyrisperidone
  • 9 OH risperidone
  • R76477
  • Sustenna, Invega

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (1993)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.129w.385.650w
  2. D03w.383.742.592w

AMA Style

References

  1. National Library of Medicine. Paliperidone Palmitate. Medical Subject Headings (MeSH). 2026. Unique ID D000068882. http://id.nlm.nih.gov/mesh/2026/D000068882
  2. Paliperidone Palmitate. In: Wikipedia. https://en.wikipedia.org/wiki/Paliperidone_palmitate
  3. Paliperidone Palmitate. In: Wikidata. https://www.wikidata.org/wiki/Q27157250
  4. Paliperidone Palmitate. In: PubChem Compound. CID 9852746. https://pubchem.ncbi.nlm.nih.gov/compound/9852746