Chemicals and Drugs

Paclitaxel

A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.

Chemical Identity

Chemical Information

Molecular Formula
C47H51NO14
Molecular Weight
853.9 g/mol
CAS Registry No.
33069-62-4
IUPAC Name
[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
InChIKey
RCINICONZNJXQF-MZXODVADSA-N
SMILES
CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
MeSH Unique ID
D017239
Source
PubChem CID 36314

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

14 entry terms
  • 7-epi-Taxol
  • Anzatax
  • Bris Taxol
  • NSC-125973
  • Onxol
  • Paclitaxel, (4 alpha)-Isomer
  • Paxene
  • Praxel
  • Taxol
  • Taxol A
  • 7 epi Taxol
  • NSC 125973
  • NSC125973
  • Taxol, Bris

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

95; was TAXOL 1993-94; was TAXOL A (NM) 1977-92

MeSH Record

Previous Indexing

  • Alkaloids (1982-1992)
  • Terpenes (1977-1981)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.392.368w.242w.888w.777w
  2. D02w.455w.849w.291w.850w.777w

MeSH Record

NLM Classification

QV 269

AMA Style

References

  1. National Library of Medicine. Paclitaxel. Medical Subject Headings (MeSH). 2026. Unique ID D017239. http://id.nlm.nih.gov/mesh/2026/D017239
  2. Paclitaxel. In: Wikipedia. https://en.wikipedia.org/wiki/Paclitaxel
  3. Paclitaxel. In: Wikidata. https://www.wikidata.org/wiki/Q423762
  4. Paclitaxel. In: PubChem Compound. CID 36314. https://pubchem.ncbi.nlm.nih.gov/compound/36314