Structured Summary
Abstract
A serine-threonine-protein kinase which senses damaged MITOCHONDRIA and protects against mitochondrial dysfunction caused by PHYSIOLOGICAL STRESS. It phosphorylates proteins on the OUTER MITOCHONDRIAL MEMBRANE to coordinate quality control mechanisms that remove and replace dysfunctional mitochondrial components. Mutations in the PINK1 gene, which encodes PTEN-induced putative kinase, are associated with PARKINSON DISEASE.
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Synonyms
1 entry terms
- PINK1 Kinase
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29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2026 (2001)
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References
- National Library of Medicine. PTEN-Induced Putative Kinase. Medical Subject Headings (MeSH). 2026. Unique ID D000099202. http://id.nlm.nih.gov/mesh/2026/D000099202
- PTEN-Induced Putative Kinase. In: Wikipedia. https://en.wikipedia.org/wiki/PINK1
- PTEN-Induced Putative Kinase. In: Wikidata. https://www.wikidata.org/wiki/Q18045837