Chemicals and Drugs

Oxyphenonium

A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect.

Chemical Identity

Chemical Information

Molecular Formula
C21H34BrNO3
Molecular Weight
428.4 g/mol
CAS Registry No.
50-10-2
IUPAC Name
2-(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxyethyl-diethyl-methylazanium bromide
InChIKey
UKLQXHUGTKWPSR-UHFFFAOYSA-M
SMILES
CC[N+](C)(CC)CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O.[Br-]
MeSH Unique ID
D010115
Source
PubChem CID 5748

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

20 entry terms
  • 2-((Cyclohexylhydroxyphenylacetyl)oxy)-N,N-diethyl-N-methylethanaminium
  • Metacin
  • Methacin
  • Oxyphenon
  • Atrenyl
  • Oxyphenonium Bromide
  • Oxyphenonium Bromide, (+)-Isomer
  • Oxyphenonium Bromide, (+-)-Isomer
  • Oxyphenonium Bromide, (-)-Isomer
  • Oxyphenonium Chloride
  • Oxyphenonium Iodide
  • Oxyphenonium Iodide, (R)-Isomer
  • Oxyphenonium Iodide, (S)-Isomer
  • Oxyphenonium, (+-)-Isomer
  • Oxyphenonium, (R)-Isomer
  • Oxyphenonium, (S)-Isomer
  • Spastrex
  • Bromide, Oxyphenonium
  • Chloride, Oxyphenonium
  • Iodide, Oxyphenonium

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92(64); was OXYPHENONIUM BROMIDE 1964-91 (see under AMMONIUM COMPOUNDS 1964-90)

MeSH Record

Previous Indexing

  • Oxyphenonium Bromide (1966-1991)

MeSH Hierarchy

Tree Numbers

  1. D02w.092w.877.648w
  2. D02w.675w.276.648w

AMA Style

References

  1. National Library of Medicine. Oxyphenonium. Medical Subject Headings (MeSH). 2026. Unique ID D010115. http://id.nlm.nih.gov/mesh/2026/D010115
  2. Oxyphenonium. In: Wikipedia. https://en.wikipedia.org/wiki/Oxyphenonium_bromide
  3. Oxyphenonium. In: Wikidata. https://www.wikidata.org/wiki/Q7116109
  4. Oxyphenonium. In: PubChem Compound. CID 5748. https://pubchem.ncbi.nlm.nih.gov/compound/5748