Chemicals and Drugs

Oxaliplatin

An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.

MeSH Record

Classification

Broader headings

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

17 entry terms
  • 1,2-Diaminocyclohexane Platinum Oxalate
  • 1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II)
  • L-OHP Cpd
  • Oxalato-(1,2-cyclohexanediamine)platinum II
  • Oxaliplatin, (SP-4-2-(1R-trans))-isomer
  • Oxaliplatine
  • Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)
  • Platinum(II)-1,2-cyclohexanediamine Oxalate
  • 1,2 Diaminocyclohexane Platinum Oxalate
  • ACT 078
  • ACT-078
  • Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II)
  • Eloxatin
  • Eloxatine
  • Oxaliplatin, (SP-4-2-(1S-trans))-isomer
  • Oxaliplatin, (SP-4-3-(cis))-isomer
  • ACT078

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1981)

MeSH Hierarchy

Tree Number

  1. D02w.257w.750w

AMA Style

References

  1. National Library of Medicine. Oxaliplatin. Medical Subject Headings (MeSH). 2026. Unique ID D000077150. http://id.nlm.nih.gov/mesh/2026/D000077150
  2. Oxaliplatin. In: Wikipedia. https://en.wikipedia.org/wiki/Oxaliplatin
  3. Oxaliplatin. In: Wikidata. https://www.wikidata.org/wiki/Q422327