Chemicals and Drugs

Orotate Phosphoribosyltransferase

The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

10 entry terms
  • OMPase
  • Orotidine-5'-Monophosphate Phosphohydrolase
  • Orotidine-5'-Phosphate Pyrophosphorylase
  • Orotidylic Acid Phosphorylase
  • Orotidine 5' Monophosphate Phosphohydrolase
  • Orotidine 5' Phosphate Pyrophosphorylase
  • Phosphohydrolase, Orotidine-5'-Monophosphate
  • Phosphoribosyltransferase, Orotate
  • Phosphorylase, Orotidylic Acid
  • Pyrophosphorylase, Orotidine-5'-Phosphate

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/defic: consider also OROTIC ACID /urine (IM) + PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS (IM)

MeSH Record

History Note

91(77); was see under PENTOSYLTRANSFERASES 1977-90

MeSH Record

Previous Indexing

  • Pentosyltransferases (1972-1976)
  • Pyrimidine Nucleotides (1972-1974)
  • Ribonucleotides (1972-1974)
  • Uracil Nucleotides (1975-1976)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.400w.725w.700w

AMA Style

References

  1. National Library of Medicine. Orotate Phosphoribosyltransferase. Medical Subject Headings (MeSH). 2026. Unique ID D009962. http://id.nlm.nih.gov/mesh/2026/D009962
  2. Orotate Phosphoribosyltransferase. In: Wikipedia. https://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase
  3. Orotate Phosphoribosyltransferase. In: Wikidata. https://www.wikidata.org/wiki/Q7103869