Chemicals and Drugs

Ondansetron

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Chemical Identity

Chemical Information

Molecular Formula
C18H19N3O
Molecular Weight
293.4 g/mol
CAS Registry No.
99614-02-5
IUPAC Name
9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one
InChIKey
FELGMEQIXOGIFQ-UHFFFAOYSA-N
SMILES
CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C
MeSH Unique ID
D017294
Source
PubChem CID 4595

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

20 entry terms
  • 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-
  • Ondansetron, (+,-)-Isomer
  • GR-38032F
  • GR38032F
  • Ondansetron Hydrochloride
  • Ondansetron Monohydrochloride
  • Ondansetron Monohydrochloride Dihydrate
  • Ondansetron, (R)-Isomer
  • Ondansetron, (S)-Isomer
  • SN-307
  • Zofran
  • Zofran ODT
  • Dihydrate, Ondansetron Monohydrochloride
  • GR 38032F
  • Hydrochloride, Ondansetron
  • Monohydrochloride Dihydrate, Ondansetron
  • Monohydrochloride, Ondansetron
  • ODT, Zofran
  • SN 307
  • SN307

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was ONDANSETRON (NM) 1987-92

MeSH Record

Previous Indexing

  • Imidazoles (1987-1992)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.129w.308.690w
  2. D03w.633.100.473.144.500w
  3. D03w.633.300.148.500w

AMA Style

References

  1. National Library of Medicine. Ondansetron. Medical Subject Headings (MeSH). 2026. Unique ID D017294. http://id.nlm.nih.gov/mesh/2026/D017294
  2. Ondansetron. In: Wikipedia. https://en.wikipedia.org/wiki/Ondansetron
  3. Ondansetron. In: Wikidata. https://www.wikidata.org/wiki/Q410011
  4. Ondansetron. In: PubChem Compound. CID 4595. https://pubchem.ncbi.nlm.nih.gov/compound/4595