Chemicals and Drugs

Oncogene Protein gp140(v-fms)

Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

14 entry terms
  • fms Oncogene Product gp140
  • fms Oncogene Protein gp140
  • gp140 v-fms
  • gp140(v-fms)
  • v-fms Protein
  • gp140 v fms
  • v fms Protein
  • v-fms, gp140
  • fms Oncogene Product gp120
  • fms Oncogene Protein gp120
  • gp120 v-fms
  • gp120(v-fms)
  • gp120 v fms
  • v-fms, gp120

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

IM; coord with specific virus (IM); /drug eff /ultrastruct permitted

MeSH Record

History Note

91

MeSH Record

Previous Indexing

  • Oncogene Proteins, Viral (1985-1989)
  • Retroviridae Proteins (1987-1989)
  • Retroviridae Proteins, Oncogenic (1990)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.624.664.520.750w.650
  2. D12.776w.964w.700.750w.650
  3. D12.776w.964w.775.750w.650

AMA Style

References

  1. National Library of Medicine. Oncogene Protein gp140(v-fms). Medical Subject Headings (MeSH). 2026. Unique ID D016281. http://id.nlm.nih.gov/mesh/2026/D016281
  2. Oncogene Protein gp140(v-fms). In: Wikidata. https://www.wikidata.org/wiki/Q78345604