Chemicals and Drugs

Olanzapine

A benzodiazepine derivative that binds SEROTONIN RECEPTORS; MUSCARINIC RECEPTORS; HISTAMINE H1 RECEPTORS; ADRENERGIC ALPHA-1 RECEPTORS; and DOPAMINE RECEPTORS. It is an antipsychotic agent used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER; and MAJOR DEPRESSIVE DISORDER; it may also reduce nausea and vomiting in patients undergoing chemotherapy.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A benzodiazepine derivative that binds SEROTONIN RECEPTORS; MUSCARINIC RECEPTORS; HISTAMINE H1 RECEPTORS; ADRENERGIC ALPHA-1 RECEPTORS; and DOPAMINE RECEPTORS. It is an antipsychotic agent used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER; and MAJOR DEPRESSIVE DISORDER; it may also reduce nausea and vomiting in patients undergoing chemotherapy.

Chemical Identity

Chemical Information

Molecular Formula
C17H20N4S
Molecular Weight
312.4 g/mol
CAS Registry No.
132539-06-1
IUPAC Name
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
InChIKey
KVWDHTXUZHCGIO-UHFFFAOYSA-N
SMILES
CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C
MeSH Unique ID
D000077152
Source
PubChem CID 135398745

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine
  • LY 170053
  • LY-170052
  • Olanzapine Pamoate
  • Zolafren
  • Zyprexa
  • LY 170052
  • LY170052

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1992)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.079.080w.738w

AMA Style

References

  1. National Library of Medicine. Olanzapine. Medical Subject Headings (MeSH). 2026. Unique ID D000077152. http://id.nlm.nih.gov/mesh/2026/D000077152
  2. Olanzapine. In: Wikipedia. https://en.wikipedia.org/wiki/Olanzapine
  3. Olanzapine. In: Wikidata. https://www.wikidata.org/wiki/Q201872
  4. Olanzapine. In: PubChem Compound. CID 135398745. https://pubchem.ncbi.nlm.nih.gov/compound/135398745