Chemicals and Drugs

Nudix Hydrolases

A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder.

MeSH Record

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MeSH Record

Synonyms

5 entry terms
  • Nucleoside Diphosphates-Linked to Moiety-X Hydrolases
  • Nudix Hydrolase
  • Nudix Proteins
  • Hydrolase, Nudix
  • Nucleoside Diphosphates Linked to Moiety X Hydrolases

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2024

MeSH Hierarchy

Tree Number

  1. D08.811w.277w.040w.600w.600

AMA Style

References

  1. National Library of Medicine. Nudix Hydrolases. Medical Subject Headings (MeSH). 2026. Unique ID D000096964. http://id.nlm.nih.gov/mesh/2026/D000096964
  2. Nudix Hydrolases. In: Wikidata. https://www.wikidata.org/wiki/Q24781279