Chemicals and Drugs

Notch3 Receptor

A notch receptor characterized by a large extracellular domain containing 34 EPIDERMAL GROWTH FACTOR-like repeats. It functions to regulate CELL DIFFERENTIATION; APOPTOSIS; and CELL PROLIFERATION. Mutations in the EGF repeats of Notch-3 are associated with CADASIL.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A notch receptor characterized by a large extracellular domain containing 34 EPIDERMAL GROWTH FACTOR-like repeats. It functions to regulate CELL DIFFERENTIATION; APOPTOSIS; and CELL PROLIFERATION. Mutations in the EGF repeats of Notch-3 are associated with CADASIL.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • Neurogenic Locus Notch Homolog Protein 3
  • Notch-3 Protein
  • Notch-3 Receptor
  • Notch3 Protein
  • Receptor, Notch3
  • Notch 3 Protein
  • Notch 3 Receptor

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Receptors, Notch (2006-2016)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.543w.750w.725.875
  2. D12.776w.930w.770.875

AMA Style

References

  1. National Library of Medicine. Notch3 Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D000071656. http://id.nlm.nih.gov/mesh/2026/D000071656
  2. Notch3 Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q24778421