Structured Summary
Abstract
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
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Broader headings
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Synonyms
14 entry terms
- Lymphoid Phosphatase
- PTPN-22 Protein
- PTPase Lyp
- Protein Tyrosine Phosphatase, Non-Receptor Type 22
- Protein-Tyrosine Phosphatase Lyp
- Tyrosine Protein Phosphatase, Non-Receptor Type 22
- PTPN 22 Protein
- Protein Tyrosine Phosphatase Lyp
- Protein Tyrosine Phosphatase, Non Receptor Type 22
- Tyrosine Protein Phosphatase, Non Receptor Type 22
- Lyp1 PTPase
- Lyp2 PTPase
- PTPase, Lyp1
- PTPase, Lyp2
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2008(1999)
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AMA Style
References
- National Library of Medicine. Non-Receptor Type 22 Protein Tyrosine Phosphatase. Medical Subject Headings (MeSH). 2026. Unique ID D054596. http://id.nlm.nih.gov/mesh/2026/D054596
- Non-Receptor Type 22 Protein Tyrosine Phosphatase. In: Wikidata. https://www.wikidata.org/wiki/Q24781435