Chemicals and Drugs

Nomifensine

An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)

Chemical Identity

Chemical Information

Molecular Formula
C16H18N2
Molecular Weight
238.33 g/mol
CAS Registry No.
24526-64-5
IUPAC Name
2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
InChIKey
XXPANQJNYNUNES-UHFFFAOYSA-N
SMILES
CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3
MeSH Unique ID
D009627
Source
PubChem CID 4528

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Linamiphen
  • Nomifensin
  • Hoe-984
  • Merital
  • Nomifensine Maleate
  • Nomifensine Maleate (1:1)
  • Hoe 984
  • Hoe984
  • Maleate, Nomifensine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

86(78); was see under ISOQUINOLINES 1978-85

MeSH Record

Previous Indexing

  • Isoquinolines (1969-1977)
  • Quinolines (1966-1968)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.531.535w

AMA Style

References

  1. National Library of Medicine. Nomifensine. Medical Subject Headings (MeSH). 2026. Unique ID D009627. http://id.nlm.nih.gov/mesh/2026/D009627
  2. Nomifensine. In: Wikipedia. https://en.wikipedia.org/wiki/Nomifensine
  3. Nomifensine. In: Wikidata. https://www.wikidata.org/wiki/Q409948
  4. Nomifensine. In: PubChem Compound. CID 4528. https://pubchem.ncbi.nlm.nih.gov/compound/4528