Chemicals and Drugs

Nisoldipine

A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.

Chemical Identity

Chemical Information

Molecular Formula
C20H24N2O6
Molecular Weight
388.4 g/mol
CAS Registry No.
63675-72-9
IUPAC Name
3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey
VKQFCGNPDRICFG-UHFFFAOYSA-N
SMILES
CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
MeSH Unique ID
D015737
Source
PubChem CID 4499

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

1 entry terms
  • Bay K 5552

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Nifedipine/analogs & derivatives (1981-1989)
  • Pyridines (1966-1980)

MeSH Hierarchy

Tree Number

  1. D03w.383.725w.203.580w

MeSH Record

NLM Classification

QV 150

AMA Style

References

  1. National Library of Medicine. Nisoldipine. Medical Subject Headings (MeSH). 2026. Unique ID D015737. http://id.nlm.nih.gov/mesh/2026/D015737
  2. Nisoldipine. In: Wikipedia. https://en.wikipedia.org/wiki/Nisoldipine
  3. Nisoldipine. In: Wikidata. https://www.wikidata.org/wiki/Q3342150
  4. Nisoldipine. In: PubChem Compound. CID 4499. https://pubchem.ncbi.nlm.nih.gov/compound/4499